University of Zurich (UZH) is one of the top Universities in Europe. UZH is famous for its strong schools in Molecular Biology and Physiology. Among 12 Nobel prize winners working at the UZH two obtained the prize for their work in Physiology and Medicine. Research school in the field of red cell research founded by Prof. Walter Rudolf Hess (Nobel Prize in Physiology and Medicine 1949) and followed up by Prof. Christian Bauer (former director of the Institute of Physiology) and Prof. Max Gassmann (director of the Institute of Veterinary Physiology). Research is focused on the mechanisms of oxygen transport in the organism, and adaptive/pathological responses to oxygen deprivation. Zurich Center for Integrative Human Physiology (ZIHP) provides a solid basis for close interaction of clinicians with basic scientists offering interaction platform and funding for collaborative translational research projects. One of the projects currently ongoing focuses on the N-methyl-D-aspartate receptors and intracellular Ca2+ as a therapeutic target for the treatment of sickle cell disease.